@sueinmn I was prescribed a Aerobika device. I was advised that I use it first thing in the morning and again in the evening. I hook my nebulizer with the saline onto it and breath through it. It vibrates and is supposed to loosen up sputum, but it is not enough at one time, so far at least, where I feel it would be a viable specimen. I use nebulized budesonide/formotorol, and also yupelri in later nebulizer sessions. So you just use the regular nebulizer medication cup and uptake the entire saline vial? Then come back later and try the deep coughs etc? I have not tried this technique, but I will give it a shot. Maybe use the asthma meds first as well. Thanks so much for the tip!