@linda0234 I went through 6 weeks of gemdoce and then 10 months of monthly infusions, followed by cystoscopies every 3 months for a year. All clear following initial TURBT until very last cysto which looked all clear, but cytology came back positive. Blue light surgery showed new cancer (CIS). So I began a clinical trial. Also infusions, but immunotherapy. Cancer came back again so I am about to start CBG treatments. I had, and am sure I will have, the same issues during the infusions - severe bladder spasms. Eventually, with the surgeon's blessing, I figured out that Valium and a Cunningham clamp got me through the procedures. During the chemo, I would take a 5 mg before the infusion and then chew another one about 20 minutes into the therapy. I still had some spasms, but far less and with the clamp on, I was able to gut it out and keep the drug in. For the clinical trial infusions, they gave me rectal Valium before the infusion and then I chewed a 5 mg Valium about fifteen minutes into the hour. Also put the clamp on. Luckily each tx was only an hour and with the new regimen, I only had slight spasms that didn't last long. During both the chemo and the immunotherapy, I had no side effects after the procedures and was able to go out, play golf, whatever. I'm hoping the BCG infusions will have little or no side effects. Surgeon said we will continue to go with the Valium. The clamp looks like a torture device, but trust me, if you begin to have a spasm and you have the clamp tight enough, you can actually force yourself to relax knowing you can keep it in and not blow it out past the catheter. It's not a fun process. I thought I had beat it, being clean for 2 years, but it's a highly recurrent cancer. I'm not ready for bladder removal/reconstruction yet, so I'll go with the next chapter.