@sharonednaramsey My understanding, simplistically.

We with bronchiectasis have overactive enzymes called DPP1 (neutrophil related which is a type of white blood cell). These enzymes make airway inflammation worse causing more mucus, leading to more infections, and more lung damage. Brinsupri blocks DPP1. As a result, the airways are less inflamed, and less prone to flares. With hope and time, we experience less inflammation, fewer exacerbations, better lung function.