@jlstjohn Your post is helpful. Are you taking any sort of stool softener as well? I changed from taking the generic Motegrity in the morning to the evening and it hasn’t worked for 6 days now. I’m hoping it helps again soon. Linzess was not great for the reasons you described but I might have to try that again. These meds are expensive but what can you do?

I was considering moving to another country for family reasons but I wonder if Motegrity or Linzess are available elsewhere and what the costs are. Really, this CIC is so bad that I worry about help away from my doctors here. On trips to the Netherlands and Croatia, where I was blocked for way too long, the ER doctors offered only our standard OTC laxative meds, baby-size enemas, and senna tea. Of course over the years those have all stopped working. If anyone lives in a country where they have similar issues, we’d like to hear. Thanks