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Pain Flares Post Pluvicto Injection
Prostate Cancer | Last Active: Dec 13, 2025 | Replies (15)Comment receiving replies
@sdaniel43
Had my first injection of Plu 10/15/25. Finished Taxotere on 6/17/25. Rough road. Dropped PSA from 12.3 down to 3.7. Increased to 4.5 in a month so we decided try Pluvicto. Positive margins on excised pieces on 2/13/12. Mostly hormone therapy since then until scan on 2/5/25 revealed 6 lesions on my liver.
I noticed intermittent pain in my lower back and right shoulder a week or so after my initial injection of Pluvicto. Got worse over the next month, some days difficult to walk for a while. Dr. said he had not had many reports of that issue. I went to a chiropractor and he saw that the illeums were probably rubbing and some interference between S1 and L5.
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@jtr495705
I had my 3rd Pluicto treatment earlier this month. After #2 and #3, I've had intense pain in a shoulder into the neck, and also my lower back for a few days. It comes on suddenly and then after a few days seems to just as suddenly let up. It doesn't seem directly related to my bone mets or to my general old-man arthritis and deterioration. (I'm pushing 78 with lots of co-morbidities.) So my suspicion is that the pain flares are the Pluvicto working, killing cancer cells, causing inflammation which sensitizes nerves. Other side effects have been manageable. My PSA after treatment #1 went from 17 to 22, but dropped to 6 after the second treatment, so it does look positive.