@minnesota10
Dear Sir or Madam, two years ago, at age 74, I was diagnosed with Boullous Pemphigoid. The diagnostic process took several weeks during which time some professional minimized the itch and agony I suffered. Thus, I am sympathetic to yours. My diagnosis was finally achieve with a punch biopsy. Since then, I have been on Dupixent which has been relatively successful in relieving the symptoms. I still have some itching and occasional blistering on my scalp, the site of the original diagnosis. I strongly encourage you as a guide to go to ChatGPT. There I found a better description of my symptoms and treatment than I was getting from any healthcare professional. I have used it as a guide for conversations with my dermatologist. You might see, for example, sequence for diagnosis:🧬 Recommended next diagnostic steps
Skin biopsy with immunofluorescence (preferably of an early blister and adjacent normal skin) — to evaluate for bullous pemphigoid or lichenoid dermatitis.
Bacterial culture of any oozing site to rule out secondary infection.
Dermatopathology review of prior Grover’s biopsy slides — to confirm or refute that diagnosis.
Autoantibody panel (BP180/BP230 ELISA) — to check for pemphigoid antibodies.
Comprehensive medication review — some drugs can exacerbate autoimmune blistering reactions.
My BP was an auto immune reaction to Nuvolimab which I took to combat metastatic melanoma. It was a successful treatment, but it was two months later that the BP occurred. I am told that I will likely be on Dupixent for the remainder of my life.
I wish you the best.