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Feedback on Linzess for Irritable Bowel-C or Chronic Constipation

Digestive Health | Last Active: Dec 5 6:57am | Replies (260)
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Profile picture for cezanne @cezanne

My IBS-C, is the initial diagnosis awaiting more info from tests. Prescribed the Lowest dose of Linzess 72mcg with no change over 1/1/2 months. Now about 1 month in on the 290mcg which I think is working: take with water on awakening and no eating or coffee etc for an hour. About 6 hours later watery diarrhea repeatedly 2-4 times until over by noon. No formed stool at all.
My CT scan two weeks ago showed a large stool load throughout my colon.
If anyone can shed light on this, I would appreciate it. Is this within the realm of what to expect and will things settle down. Any tips welcome.
I have a sliding hiatal hernia (not severe symptoms but occasional nausea and fullness) and silent reflux.
Thanks

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Replies to "My IBS-C, is the initial diagnosis awaiting more info from tests. Prescribed the Lowest dose of..."
Lisa Lucier, Moderator | @lisalucier | Dec 2 4:28pm

@cezanne - Hi. Since you mentioned IBS-C and taking linaclotide (Linzess), I thought you might like to be part of this thread where others are discussing this same topic:

- Feedback on Linzess for Irritable Bowel-C or Chronic Constipation https://connect.mayoclinic.org/discussion/feedback-on-linzess-for-irritable-bowel-c-or-chronic-constipation/

I'd like you to meet @sue225 @mrsbv @grateful4life22 @tarmansbks @astaingegerdm and others, who may be able to tell you from their experiences or things they've read or observed in others about whether this progression you mentioned with taking linaclotide (Linzess) is as expected:

cezanne, you said you take it with water on awakening with no eating or coffee, etc., for an hour. About 6 hours later you have watery diarrhea repeatedly 2-4 times until it's over by noon. No formed stool at all. You also said your CT scan two weeks ago showed a large stool load throughout your colon.

Will this continue this way, or will it settle down as cezanne takes this medication?

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