If anyone knew the answer to your question, they would likely win the Noble Prize for Medicine! 30% of all neuropathy is idiopathic. I spent a week at the Mayo Clinic Rochester in June 2021 in the hopes they could find a cause for my neuropathy. They did not. I will have had this disease for 10 years in January 2026. BUT, let me say this. My burning in my feet is better. I take 60mg of Cymbalta, 100mg of Lyrica daily and low dose naltrexone for my neuropathy. I think my neuropathy is better because I have a rigid weight training programs and some cardio thrown in for good measure. I really don’t think the drugs have made a huge difference.

As you known, neuropathy treatment is solely directed toward symptom relief. Nothing out there actually reverses the damage to the nerves, so no cure is available and will likely take many years to become available, if ever. The fact that very few companies have made real progress in finding a cure after this many years is depressing.

@mrmacabre sounds bad. I looked it up. Seems no cure. I just understand that when vit B12 is low, nerves become demyelinated from brain to toes. I take
25 micrograms daily. Has your B12 been measured. Good luck
James