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About to start treatment with Proton, question about ADT
Prostate Cancer | Last Active: Nov 26, 2025 | Replies (15)Comment receiving replies
Well...update. I'm no longer eligible for the GU10 study because my newest Decipher came back 0.52, and it required less than 0.4. While this is good, because I was fairly certain that had I drawn the arm with ADT I would have withdrawn, now I am wondering if I *should* do the ADT. I know my oncologist is pushing for it, but the side effects worry me more than the treatment itself.
Replies to "Well...update. I'm no longer eligible for the GU10 study because my newest Decipher came back 0.52,..."
@mcan56 I am 65 and started this whole adventure with a PSA of 5.5 and Gleason 7 (3+4), but due to some other factors was diagnosed unfavorable intermediate. I decided on a 28 treatment proton therapy and my RO and MO recommended 6 months ADT, specifically Orgovyx. I was very hesitant to do the ADT as I was also very worried about the side effects, but after a lot of research and reading I decided I could live with 6 months if it increased the chance of a positive outcome. I had read about the positive benefits of exercise and since I have been running and lifting for years I just continued my workout schedule. I don't know if it was the working out, my genetics or chance (maybe all three), but I had almost no side effects from the Orgovyx. I did have loss of libido, and a few warm flashes, but that was about it. My testosterone went from 6 to 116 one month after stopping the ADT. I have my next blood test next week, 4 months post treatment, and I'm interested to see what it is.
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@mcan56 At 55y, if you’re able to engage in resistance-training exercises, you’ll tolerate ADT well.
There has been much reported on the physical benefits of exercise while on ADT. Here are just a few that I’ve bookmarked:
> Drs. Scholz and Moyad talking about exercise and hormone therapy: https://m.youtube.com/watch
> A paper on The Benefits of Exercise During Hormone Therapy: https://static1.squarespace.com/static/54c68ac6e4b06d2e36a4b8c9/t/55cb7275e4b0d97ae7ff60af/1439396469154/The+Benefits+of+Exercise+During+Hormone+Therapy_Insights+August+2015_PCRI.pdf
> A study about the benefits of exercise to counteract the adverse effects of ADT: (They also describe a good resistance-training program): https://journals.lww.com/acsm-msse/fulltext/2023/04000/resistance_exercise_training_increases_muscle_mass.2.aspx
If you do what it takes, you’ll do very well with the hormone therapy - it’ll just be an annoyance; if you don’t do anything, hormone therapy can be your worst nightmare.
For me (a gym rat), ADT was a walk in a park.