@damcipro Not exactly. I was on antibiotics for over 18 months, the last 6 of those daily (did not qualify for Arikayce trial at the time.)
By the 4th month of daily meds, my sputum cultures were all over the place, in a group of 3 one or two would be negative, the others positive - this happened 3 times. At the same time, the daily meds were ruining my health and life, I had no energy, was down by over 20% of my body weight, depressed, daily aches & headache. My ID doc & I, with concurrence of my pulmo, stopped the meds, BUT started 7% daily saline nebs ( they were just becoming the thing to do in US.)
Since then , my cultures twice a year, have been negative for MAC and pseudomonas. And once my asthma was under control, my cough improved and my CT shows the bronchiectasis is stable.