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High PSA, but MRI is negative. Biopsy or Not?
Prostate Cancer | Last Active: 7 hours ago | Replies (55)Comment receiving replies
I would recommend you go for a biopsy. I was 68 last year (July 2024) with a PSA of only 2.0. The MRI was negative, DRE negative and ultrasound negative. When I requested a biopsy. The doctor guided the procedure with ultrasound since MRI was negative. While doing the procedure he commented that there were no shadows no nothing . He went ahead and took the 12 cores saying there was likely no cancer. Two weeks later he tells me I have PC.. Gleason 3/4. Pathology after surgery was a large tumor occupying 10% of the gland with Gleason 3/4 (30%- gleason 4).
So to answer your question about ultrasound, it did not see anything in my case. Everyone is different and to be honest the biopsy was not that big a deal and in my case it was the only tool that found the cancer.
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@beachflyer
Can I asked. When you had your biopsies where they done MRI/Fusion? Or since MRI was not showing suspicious areas they did a ultrasound? Is not a ultrasound a lot less informative than a MRI?
When you had your MRI did they use a contrast? The contrast gives a much clearer and defined picture of the prostate.
In my case I had MRI done with contrast. Did not find tumors/lesions just suspicious areas. Many many PCs are at the cellular level meaning only the cells are different than normal cells not that you have a tumor or lesion. This was my case I had not tumors or lesions.
I am not sure the hesitation of biopsies as they really do reveal if you have PC. With the caveat that need to be done correctly and enough areas of prostate to get a good report.