Completed 6 Pluvitco Injections. Oncologist moves me to Lynparza.

@jxj
I didn’t realize you completed your treatment. What did your scan show after.

@jeffmarc
Thank you

@jxj My radiologist and oncologist are in agreement that they will not do a scan until we're at least 4 weeks after the last Pluvicto treatment. Given the holidays, that means after the start of the new year. Frankly I have no idea what to expect.

Thanks for sharing. My husband will be starting on Pluvicto on Dec. 8th. Did you have any reactions to it?? Is it true you must stay away for 3 days ? Pets included ? The whole nuclear thing about it is just so scary to me. BTW my husband has Stage 4 Prostrate Cancer that has mestasasized. Thanks again

@ewatson201
You do need to keep that 6 foot distance. Pets included.

People go on Pluvicto when they have metastasis, Never heard of anyone getting it without them.

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.

If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works.

You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.
https://connect.mayoclinic.org/comment/1380711/
other comments about Pluvicto

I am 86 and will have my 4th Pluvicto infusion today.
I had 9 treatments of Chemo. The PSA started out at
86 and got down to 7. Chemo was a real bitch. Then after 11 months the PSA was back up to 80 and I started Pluvicto. My PSA has dropped like a rock. 80 to 40, then 40 to 13 and now 13 to 5.5.
My side effects have been minimum. Way better than chemo.
I am one of the lucky ones that Pluvicto works on!

My husband had six Pluvicto infusions over most of 2024 and had none of the severe side effects that some people experience. He had some fatigue, a dry mouth from his saliva glands being affected by the treatment, and his appetite for food decreased in that most things just didn't appeal to him. His last Pluvicto infusion was in August 2024, and the only side effect remaining is dry mouth.

@jeffmarc

Thank you for responding. It is hard to find people who have had Pluvicto. He was diagnosed last Nov 1st and was only on meds till This past September when his PSA was 181 !!!!
He has had 10 rounds of radiation at the hospital and waiting for approval for Pluvicto treatment from our insurance. As of now it will be Dec 8th. My husband is 75, has A-FIB and has lost 100 pds since last year. He needed to thou, he was almost 294. The hardest part of this is I donlt know how long I will have him in my life. We have been married for 49 years, two beautiful daughters and have been best friends since 1978. I wish you nothing but health for a very very long time.
Ellen Watson

@ewatson201, you may be interested in these related discussions where others have shared their experience with Pluvicto:
- Anyone on Pluvicto? Looking for a support team https://connect.mayoclinic.org/discussion/anyone-on-pluvicto/
- Can anyone share their experience with Pluvicto? https://connect.mayoclinic.org/discussion/can-anyone-share-their-experience-with-pluvicto/

See all https://connect.mayoclinic.org/search/discussions/

I see you're asking about the precautions necessary after treatments. With proper attention to instructions from your husband's radiation oncologist you can keep everyone safe

Read more about what to expect and precautions on Pluvicto's website here https://us.pluvicto.com/about-pluvicto/what-to-expect-when-taking-pluvicto

For more complete details, you can also download the pluvicto_patient_e.pdf Patient Information Insert.

Here's a relevant excerpt

After administration of PLUVICTO
For 2 days after the administration of PLUVICTO, drink plenty of water in order to remain hydrated and to urinate as often as possible to eliminate the radiopharmaceutical product from your body.

Because this medicine is radioactive, you will have to follow the instructions described below to minimize radiation exposure to others unless otherwise instructed by your nuclear medicine doctor.

Contact with others in your household, children, and/or pregnant women
 limit close contact (less than 1 meter) with:
o others in your household for 2 days
o children and pregnant women for 7 days;
 sleep in a separate bedroom from:
o others in your household for 3 days
o children for 7 days
o pregnant women for 15 days;
 avoid sexual activity for 7 days;
 use effective birth control throughout treatment with PLUVICTO and for 14 weeks after your last dose.

Use of toilets
Take special precautions to avoid contamination during the 2 days after treatment.
 You must always sit when using the toilet.
 It is essential that you use toilet paper every time you use the toilet.
 Always wash your hands well after using the toilet.
 Flush all wipes and/or toilet paper down the toilet immediately after use.
 Flush any tissues or any other items that contain bodily waste, such as blood, urine and feces
down the toilet. Items that cannot be flushed down the toilet, such as bandages, must be placed in separate plastic waste disposal bags (according to “Waste disposal recommendations” below).

Showering and laundry
Take a shower every day for at least the first 7 days after treatment. Wash your underwear, pajamas, sheets and any clothes that contain sweat, blood or urine separately from the laundry of others in your household, using a standard washing cycle. You do not need to use bleach and do not need extra rinses.

Waste disposal recommendations
All items to be thrown away should be discarded in a separate plastic waste disposal bag to be used only for this purpose. Keep the plastic waste disposal bags separate from the other household waste and away from children and animals. A member of the hospital staff will tell you how and when to get rid of these waste disposal bags.