@meingan Though I have successfully lowered my dose from 150 mg to 37.5, I have done so because of it's sexual side effect. My sexual organs were numb, which is common with this medication. I have been slowly switching to Mirtazapine because it has a reputation of no sexual side effects and I am fortunately finding this to be true. I think the main reason people don't want to stay on Effexor is because they would like to enjoy sex again. Plus I have found taking CBD oil has made it quite easy for me to switch medications with very little discomfort.