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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: 5 days ago | Replies (304)Comment receiving replies
How much can lack of sleep affect CTX values? For some reason, I was only able to sleep in half hour to hour periods of time before my recent blood draw. My CTX value 2.5 years ago was 210; now it was 326. Patiently waiting for the P1NP result. Don't want to have my endo try to frighten me about the increase if not necessary. I have not started any treatment yet.
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@normahorn
I’ve read some studies on this. My takeaway is that in postmenopausal women, CTX levels do not significantly increase after acute sleep restriction, unlike in healthy premenopausal women where increases of around 30% have been observed. The effect on P1NP (usually a decrease) is also less pronounced in postmenopausal women. However, chronic sleep disturbances could contribute to higher CTX levels over time.
Given that, the increase from 210 to 326 over 2.5 years is more likely due to natural long-term variation in bone turnover rather than a single night of poor sleep. The acute sleeplessness may have a small effect on CTX, but it may not be enough to explain this magnitude of change (a 55% increase). A CTX of 326 is still fairly “calm” in terms of bone resorption, so it will be very interesting to see what your DXA shows with these lower-level CTX values.