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High PSA, but MRI is negative. Biopsy or Not?
Prostate Cancer | Last Active: Dec 8, 2025 | Replies (55)Comment receiving replies
@rider51 thanks for the reply. My urologist first mentioned the newer urine and blood diagnostic tests last year, but then dissuaded me from them during my visit last week, when he was pushing for a biopsy. After researching some of these tests, it seems to me that they should be part of the clinical progression, especially for someone like me, who has had a MRI that showed nothing (it is a year old now). I'm thinking I should get something like ExoDx AND a new MRI before I go for a biopsy.
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@lookin4answers
I agree with your thinking. I posted a more complete summary of my story below which you can read for some more of the details of my particular case. Although I am extremely appreciative of the ExoDx test for pointing me toward what until then had been undetectable cancer, I do think there are better tests available now than the ExoDx. One of the other members on this forum is Jeff Marchi (@jeffmarc) and he has a summary chart that lists a number of the genomic type tests currently available with the accuracy that they are rated at - hopefully he will see this and post that chart for your reference. My recollection is that the best currently available test is the PSE test. So, my recommendation to you would be to ask your urologist to prescribe the PSE test and go on from there depending on that result and your urologists recommendations.