I began Tagrisso 80mg on August 1. Normal for the first week. After that the diarrhea started and was severe. I took Imodium daily but then got backed up. Never been constipated my whole life. After 5 days I had a hard movement. Then I decided to only take Imodium when eating out and just suffer at home. Doctor said no, frequent diarrhea can cause a host of problems on its own. Kept getting worse. The dose was reduced to 40mg. That helped a little but still came. A friend suggested Kefir. It's been helping. I have soft stools and occasionally watery. I will combine it with drinking Kefir. I have to take Tagrisso for three years so this is a journey. Any advice is greatly appreciated.