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Enhertu: How are you coping?

Posted by margitdill @margitdill, Aug 14 7:57am

I have been put on Enhertu for stage 4 cervical cancer. The first cycle I was given the full dose. I was so sick with weakness, extreme fatigue, queasiness, chills, sleepiness, etc. J did not feel that I could tolerate it. This misery lasted about 12 days. After reporting these issues to my oncologist, he suggested that I go on a lower dose which I did the second cycle. The after effects were much less extreme, so that was a good decision. Enhertu is the last drug to be tried - which is scary. I do not know what is next. Anyone else in a similar situation?

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margitdill | @margitdill | Nov 21 8:31am
In reply to @maryg74 "@cookercooker It eases my mind to read your post. I have metastatic breast cancer with bone,..." + (show)
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@cookercooker
It eases my mind to read your post. I have metastatic breast cancer with bone, liver and lung involvement and it just spread to peritoneum. My oncologist wants to put me on Enhertu and that drug scares me. She says it's a really effective treatment option and the best option we have. Seeing your post makes my decision to say yes a little more comfortable. Good luck to you and I hope you continue to stay well treated.

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@maryg74 hi yes it is a good drug. But I had to go off it because I experienced one of the listed serious side effects of it. Everyone reacts differently… we are talking clinical trials now. Prayers for you!

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margitdill | @margitdill | Nov 21 8:31am

I agree … I do not have much nausea fortunately!

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cookercooker | @cookercooker | Nov 21 11:02am
In reply to @maryg74 "@cookercooker It eases my mind to read your post. I have metastatic breast cancer with bone,..." + (show)
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@cookercooker
It eases my mind to read your post. I have metastatic breast cancer with bone, liver and lung involvement and it just spread to peritoneum. My oncologist wants to put me on Enhertu and that drug scares me. She says it's a really effective treatment option and the best option we have. Seeing your post makes my decision to say yes a little more comfortable. Good luck to you and I hope you continue to stay well treated.

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@maryg74
Update to make help make your decision even easier:
Have received 13 rounds of Enhertu to date. CT scan shows target tumors resolved. Affected lymph node is stable. No dangerous side fx to lungs and heart. GI problems still an issue - swinging back and forth between diarrhea and constipation, and nausea, but not as bad this last time around. Fatigue still an issue: more of a weariness, which may also be due to having to fly to Kelowna every three weeks from Victoria for treatment.
Have been approached to be BCCan "poster child" for the treatment.
Continuing with the treatment with no idea when it will end. I'm told it will end when the treatment stops working or the cancer progresses. What's next? I asked, and the doctor mentioned immunotherapy.
Remember, that Enhertu has already been approved for breast cancer. I'm on a trial testing it for endometrial cancer.
Hope this is encouraging news.

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alohman08 | @alohman08 | Nov 21 12:52pm
In reply to @maryg74 "@cookercooker It eases my mind to read your post. I have metastatic breast cancer with bone,..." + (show)
Profile picture for maryg74 @maryg74

@cookercooker
It eases my mind to read your post. I have metastatic breast cancer with bone, liver and lung involvement and it just spread to peritoneum. My oncologist wants to put me on Enhertu and that drug scares me. She says it's a really effective treatment option and the best option we have. Seeing your post makes my decision to say yes a little more comfortable. Good luck to you and I hope you continue to stay well treated.

Jump to this post

@maryg74 Hi Mary...I've been receiving enhertu infusions since May of this year...My scans have been excellent NED which means its working...I have extended the time between treatments to every 4 week instead of every 3 because I find the side effects unpleasant. They have been manageable. but I don't really feel great until day 14 ! I have not been nauseous but my appetite is not good .....very little appeals to me...fatigue hasn't really been an issue, my exercise schedule remains the same...needed to rest in the afternoon on days 3 & 4....My hair has gotten very thin and that's been upsetting... I'm hoping that the dose I'm getting can be decreased so that I will feel better sooner...something my oncologist and I have been discussing....unfortunately it appears to be a maintenance drug with no end in sight ...but the flip side is that it is doing what it needs to do and thats really all that matters !

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