I’m on Trulance 3 mg which I take in the morning with a glass of water. Then I have coffee followed by fiber rich cereal and fruit. On the afternoon I take MiraLAX with water. Some days it works great other days nothing. Presently it’s been 2 days since I got relief. I’ve been under stress which doesn’t help. Anyone have suggestions?

I have IBD-Crohn’s. BTW

@bernadette8 - welcome to Mayo Clinic Connect. Sorry to hear nothing is moving, despite taking these medications. I could see where also arriving at the polar opposite, diarrhea all day, is also really undesirable. Interesting that the results with differing dosages are similar.

Have you taken any other medications or used any other tactics to alleviate your constipation? If so, how have they worked?

@bernadette8 Same thing happened to me with Linzess. I am now having success using Motegrity in the morning along with CALM magnesium oxide powder every afternoon/evening. Motegrity (prucalopeide) did not work initially but I stopped for 2 weeks and then tried again and it started working for the past month. I like that it hasn’t given me day-long diarrhea, just one or two usually normal bm’s in the early morning. Needed my gastro’s office to get my insurance to cover it as “necessary.” Not a drug usually covered.