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DiscussionHow many of you have tried Lyrica (Pregabalin) in doses from 600 mg?
Chronic Pain | Last Active: Dec 7, 2025 | Replies (26)Comment receiving replies
Replies to "@georgescraftjr I am 73. I play video games and love puzzle games. Lyrica has never posed..."
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@ardeecor
My husband is 83, He took lyrica and opiods for years to treat lower back pain, and he has Alzheimer's, vascular dementia, Lewy Body and Parkinson's.
Here are links to studies regarding a connection between the use of lyrica and dementia:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10266423/
https://www.pharmacytimes.com/view/gabapentin-use-linked-to-increased-dementia-risk-in-chronic-back-pain-patients
See also post from neuropathy support writer:
Gabapentin - being linked to increased risk of dementia
Posted by mikead63 @mikead63, Jul 12 12:12pm
According to a large scale observational study published in the journal "Regional Anesthesia & Pain Medicine", patients who received frequent gabapentin prescriptions were significantly more likely to develop dementia and/or mild cognitive impairment (MCI).
Researchers analyzed anonymized medical records from tens of thousands of Americans sourced from TriNetX, a federated health research network with electronic health records from 68 healthcare organizations across the country.
They found that patients whom had received six or more gabapentin prescriptions were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with MCI within 10 years of their initial pain diagnosis.
There is more - To view the full report:
https://doi.org/10.1136/rapm-2025-106577