The COVID-19 vaccine targets the SARS-CoV-2 spike protein, which can prep the immune system to respond better to immunotherapy, but it was not tested with all treatments or cancer types. According to the study, the Covid vaccine sends antiviral signals that wake up immune cells, letting more of them reach tumors, increase PD-L1 levels and make immunotherapy work better.

I think the Covid Vaccine is supposed to cause an immune response in your lymph nodes which pulls the white blood cells that have mutated away from the cancer so the immunotherapy can more readily recognize and attack the cancer. If your cancer is in your lymph nodes this idea may not be applicable. Hopefully the increase in activity is just a data point and not a trend. I am wondering if the covid vaccine had a temporary effect on your PET scan that will resolve before your follow-up.

Hang in there:)

Hang in there!