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Just diagnosed: Surgery not an option, looking for hope
Colorectal Cancer | Last Active: Mar 12 8:29pm | Replies (98)Comment receiving replies
@vcsongradi I have KRAS G12S so there are few options except clinical trials. I may get the genotyping redone and get second opinion also because this mutation is quite limiting for treatment.
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@tiffbrueggeman
Rectum, mass, biopsy:
INVASIVE, MODERATELY DIFFERENTIATED ADENOCARCINOMA. (SEE COMMENT)
Comment
Immunohistochemical studies were performed at the outside institution and reviewed at MD Anderson. The tumor shows preserved nuclear expression of MLH1, PMS2, MSH2 and MSH6. Therefore, the likelihood of defective DNA mismatch repair/high levels of microsatellite instability (MSI-H) in the tumor is low.
The tumor was genotyped and nothing significant was found that would benefit from targeted therapy.