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Osteoporosis & Bone Health | Last Active: Nov 18 3:01pm | Replies (84)
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@tkdesign
I don’t know how sound this info is but it’s from drugs dot com
“Prolia (denosumab) helps build bone by increasing “bone mass” and reducing the risk of fractures in individuals with osteoporosis. It works by blocking a protein that leads to bone breakdown, making bones stronger.” I know it’s not an anabolic but it works differently…
My understanding is that Forteo, Tymlos (parapeptides) and Evenity are the bone builders. I’m not sure how Prolia works exactly I think it’s a monoclonal. RANK ligand (RANKL) inhibitor FDA approved for treating:
Osteoporosis in postmenopausal women who are at a high risk of fracture.
Replies to "@tkdesign I don’t know how sound this info is but it’s from drugs dot com “Prolia..."
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@osteopatient2026 Prolia suppresses the bone-breakdown cells (osteoclasts). If Prolia is stopped, those osteoclasts return with a vengeance: the “rebound effect”. You can lose all your bone density gains, and even end up worse than you were before.
The anabolics like Tymlos, Forteo, and Evenity work on the other side of the equation: they stimulate the bone-building cells (osteoblasts.) You still need to follow up with a biphosphonate, but the potential loss of density without a follow-up is not as severe as with Prolia.