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Does Benadryl (as needed) cause weight gain?
Depression & Anxiety | Last Active: Nov 17, 2025 | Replies (7)Comment receiving replies
My doctors want me to take Benadryl at bedtime to address it chronic inflammation that is part of Erythromelalgia and I don’t want weight gain why would taking it at bedtime cause that? I take Tramadol during the day for chronic pain and I was on Gabapentin that doesn’t work I never gained weight on these drugs does it always happens with Benadryl?
Replies to "My doctors want me to take Benadryl at bedtime to address it chronic inflammation that is..."
@abbybarnes, I would start by asking your doctor how often and for how long you will need to take Benadryl to address the inflammation. Long-term regular use is associated with health risks. Occasional short-term use is generally safe for most healthy adults.
Please check with your doctor and let them know about your weight gain concerns too.
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Benadryl Is Great for Insomnia! I have taken it for years when I have trouble sleeping because of my neuropathy pain in my feet!
Not well known that it offers an alternative to OTC sleep drugs!
Thanks
Sundance, aka RB