@robe1018,
hi. the endocrinologist I see thinks that the whole headache syndrome with Tymlos is because of vasodilation of the blood vessels. The medication works because parathyroid hormone we inject tells your body that you are low calcium. It sets off reactions that pull calcium back from your kidneys, draws it from your digestive tract and from your bones and into your blood. Drawing calcium from intracellular spaces relaxes blood vessels. Gradually over the serum calcium returns to normal, but meanwhile,
widening blood vessels in the head stretches pain receptors there and can stimulate the trigeminal nerve to produce chemicals that cause migraine-like throbbing.
All the medications we take (for everything) set off chemical chain reactions unrelated to the illness and often unknown even by our professionals. Our bodies make the discovery sometimes unfortunately for our health.
A single study determined dosage. https://link.springer.com/article/10.1007/s00774-023-01455-6 which would tell us how many were enrolled. In the study side effects were said to be not dose dependent. I don't have access to the study itself.
The Tymlos pens are of a fortunate constuction--maybe intentional.