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Side effects of Orgovyx (relugolix): Anyone have stomach or GI issues?
Prostate Cancer | Last Active: Nov 18, 2025 | Replies (16)Comment receiving replies
Hello! I’m 9 months into an 18 month course of treatment on Orgovyx. I seem to be a poster child for bad side effects, especially gastrointestinal. I’m 74 years old, and was previously in good health. My biggest issue is cramping, although there is bloating, weight gain, fatigue, joint pain, and swollen hands. So far I’ve tried different diets, different times of the day, and both an empty and full stomach. While my PSA is zero and my markers look good, I’ve gotten no answers from my doctors other than varying amounts of gas-x depending on the severity of the cramps. They go from a pain level of 2 to a pain level of 9. It’s brutal. This week I’m seeing my PCP to see if she can further guide me to a GI doc. I sleep 9-12 hours a night, work with an exercise physiologist, and have always watched my diet very carefully, with red meat treated as a condiment. Has anyone found a reliable method of relief? I will post if my test results give a good clue as to resolving this. Stay as well as possible.
Replies to "Hello! I’m 9 months into an 18 month course of treatment on Orgovyx. I seem to..."
@dogrocketp No one really knows the FULL extent of SE’s when you chemically castrate a male. Although GI symptoms are not usually high on the list, it doesn’t mean they can’t happen.
Look into the FODMAP diet and see if that might work for you. Usually recommended for those with irritable bowel, Crohn’s and other GI maladies.
Adding more fiber, could, in fact, make your symptoms worse. (You don’t mention constipation or diarrhea).
The type of fiber you eat is critical in combating bloating, cramps and gas. You may require non-fermentable types instead of the commonly used psyllium, bran and cereal based ones.
Amazon carries Healthy Fiber - a guar gum based powder which will keep you regular with NO gas or bloat.
I followed a FODMAP diet during my SRT to prevent gas but stay regular enough to maintain an empty rectum. It’s not difficult, but you MUST follow the diet and not cheat. Be sure to drink a LOT of water to keep your bowel hydrated.
After a few days of eliminating trigger foods (most of the gas producing foods we all love!) I think you’ll begin to see a difference…Best,
Phil
@dogrocketp I think you better suggest to your doctor that you should go on “vacation @ since you have 0 PSA. And then start taking Orgovyx again when your PSA goes up like.5 or 1 whatever you agreed with your doctor. I have read a few in this blog that they were told to go on vacation when their PSA is less than .1 so why not try it. You been suffering from continuing to take the medication, so take a break.
@dogrocketp look into FODMAP diet…tailored for IBS and other GI disorders. Who knows what ADT does to every single individual?
Phil
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@dogrocketp
One thing you could try is eating one shot glass of bran buds every day. This was brought up at the PCRI conference. Can’t remember who said it, but the doctor said it makes you regular. I bought a box of Kellogg’s bran buds And use a shot glass full every morning. It has made me regular, Something that was hit and miss before.
You do need to drink a fair amount of water every day to make your stool is not real hard. If that is a problem you have.
I’ve been on ADT for eight years and I’ve never had the problem you describe, Been on Orgovyx For almost 3 years.