I have been in Letrozole since April 2025. Just eight months. I have had some hot flashes and when I went off it for two weeks for some surgery i had to have because my one implant had capsular contraction and a seroma under the implant and had to be removed and replaced this September. I found when I was off and went back on I had terrible night sweats and hot flashes for a week but they subsided when my body got used to the drug. I have had a little hair thinning but use vegamour shampoo and conditioner and that is ok now. I also periodically have some joint pain but nothing terrible. I lift weights and work out every day with stretching and yoga and walking and doing lymphatic exercises to keep the lump system draining. I had invasive lobular cancer stage 1A grade 2 and no lymph nodes involved. I had a bilateral mastectomy in February because this type of cancer likes to come back and it reduced the likelihood of return surgically from 15% with a lumpectomy to 2% with mastectomies so it wasn’t even a hard choice to have the latter. Reconstruction went well except for this capsular contraction and there is at least one study suggesting women in AI have a greater likelihood of having it happen. I am taking singular and VIT E to counter the likelihood of it happening again. Even with the AI I am told I have an 8% chance of the cancer returning - my oncotype score was 22. Never had to do radiation or chemo thankfully. So I am taking the letrozole and being monitored regularly for cardiology and bone loss issues and having blood work
Tested regularly. I think we should remember that all drug manufacturers have to put any side effect mentioned by those in trials and just because they list it doesn’t mean it will happen to you. I am staying positive and not looking for issues but rather staying very active, eating well and breathing and stretching and weight lifting to ward off any issues. We will see what happens. I have four years and 4 months to go and am keeping my fingers crossed! Good luck to you.