@briarrose I have been on letrozole for 3 years with no real side effects. Maybe a handful of hot flashes in the first few months. My bone density is still normal. My advice would be that if you are feeling side effects you record what is going on in a daily journal. Then you can look more objectively at the trend. Also, if at all possible, try not to worry too much. You can go off this drug or have your oncologist switch AI's...basically the decision is yours. I was worried and cynical! The letrozole has kept my rare aggressive cancer at bay. So far so good. Wishing you all the best, and to everyone as well.