@starlight1 I started getting small callous like lesions on my legs after about two weeks. I had a couple of what looked like small open soars on my hands and arms. It wasn’t a rash though. There was one in my leg where the skin was peeling. I must say I am super sensitive to medications. My doctor at Mayo took me off brinsupri and I will see a dermatologist. We may try lowering the dose to 10 mg instead of 25mg after we see what the dermatologist says.