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ADT, maybe not? Anyone opted out of ADT?
Prostate Cancer | Last Active: Mar 27 2:12pm | Replies (138)Comment receiving replies
On year 13 with this disease. Have been under treatment for 11 years. I have had Radiation, Firmagon, Lupron depot of various strengths, Orgovix, Eligard, Zytiga, prednisone, Dexamethasone, denosumab. For several years PSA was controlled and became negligible after each injection. The last couple years it has increased to over 19 regardless of treatments. The last 2months, after adding Dexamethasone to Zytiga and Eligard PSA decreased to 6.25. This has been disappointing and expecting an addition to my treatments.
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@duberdicus
Have you had a PSMA Pet scan to see if there are noticeable metastasis. If so, they can be zapped with SBRT radiation. I’ve had it done to mine had one in the spine I had zapped.
I was diagnosed 16 years ago and had surgery a few months after and 3 1/2 years later salvage radiation.. When Lupron stopped working I went on Biclutamide and then Zytiga and now Orgovyx with Nubeqa, which has kept me undetectable for the last 24 months. I have a genetic problem BRCA2 Which prevents my system from correcting DNA error so I’ve had four reoccurrences.
Dexamethasone is supposed to work a lot better with Zytiga, but it has its limits and you seem to be beyond them. I was on Zytiga for 2 1/2 years and my PSA was only undetectable one month in that time. Switching to Nubeqa Has been a real eye-opener since I’ve gone so long undetectable. Not only that, but its side effects are very few, if any, I haven’t noticed anything. It can also reduce your brain fog because it Doesn’t pass the blood brain barrier like Zytiga.
Speak to your doctor about switching drugs, It may make a big difference for you and it’s worth trying at least. Zytiga has just really miserable side effects, It’s worth getting off of.