Depression and hormone therapy

Posted by madisonman0326 @madisonman0326, Nov 13, 2025

I was diagnosed with stage IV PC (Gleason 4+5 =9) and started Lupron and Zitiga shortly thereafter. I had six weeks of radiation which I finished on August 30th.
I was fortunate as not to have hot flashes or fatigue but the heightened emotions have been a problem. Normally, I am a pretty happy, go lucky guy but lately I have had bouts of depression like I haven’t seen since my teenage years decades ago (I’m 67).
My partner was twice married before we met a dozen years ago and I had also been married once and discussions of our previous marriages was like the third rail in our relationship - don’t touch it!!
But, now that my libido is compromised, I keep thinking about how much sexier her two husbands were compared to me in my present state and, I admit, I am jealous…which I know is completely irrational because she divorced them. Still…
To her credit, she has never asked me about my history. I was a semi-pro athlete who traveled often and, well, that old saw about girls liking jocks has a ring of truth but she doesn’t want to know the details and I would be hesitant to provide them.
But my thoughts turn to the idea that, as a chemically castrated senior, I am not quite a complete man and maybe she’d be better off with a more virile man.
My oncologist is aware of the depression and has recommended therapy but I hesitate because I am reluctant to take additional meds should I be prescribed anti-depressants. I did see a therapist once, just prior to meeting my partner, but that wasn’t in a professional capacity.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Exercise and doing something for someone else helps get us out of our head. One makes you feel better the other gives you purpose.

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Getting outside, visiting a friend, seeing that there are others not as well.
It seems my life has been put on hold for 2 years with fatigue from treatment. More down days
than up. IT can be difficult. This site helps.

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Profile picture for madisonman0326 @madisonman0326

@heavyphil
Thanks. Actually, in full honesty, I can still perform sexually and I believe being an athlete and maintaining a training schedule is a big factor in that area but I worry about losing that ability because my radiation oncologist, a man, told me, flat out. that, post radiation I won't be able to get an erection because the process destroyed the nerves necessary for that function. He offered to prescribe Viagra because my regular oncologist is a pretty young woman and I might be shy about asking her for a drug to enhance my sexual performance.
"Ann" has been very supportive in this journey and recently we had some frank discussions about our relationship, some of which were a surprise to me. We had friends in common when we met, which can be wonderful and which can be alarming. One mutual friend, Gaila, warned"Ann" that, although I may give off the choir boy vibe (which, admittedly, I do) I had actually "Played the field" and I was hardly innocent. Until now, I didn't know she knew - I thought she thought I had gone straight from marriage to a relationship with her!
Ann did know, however, that I was just about to lock down a relationship with another woman, "Brittany" - a fair -skinned Irish beauty who, at fifty, retained the good looks of her youth - before she, Ann, ran an interference play and I dated both of them for a while - although I was only intimate with Ann. Ann traveled frequently and, when she wasn't available, I would hit the clubs with Brittany...which was really unfair to both women. Brittany should have dropped me and pursued an available man and Ann should have given me given me the classic ultimatum: Me or her. But, really, it was up to me to make the decision and I didn't. I believe in equal rights for women but, if the shoe was on the other foot - if Ann went clubbing with another man while I was out of town - I would have gone ballistic. I like women but I'll never understand them

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@madisonman0326
It is strange that a radiologist would tell you that would happen right away. Most men who have radiation can get an erection after, A few years later, it frequently becomes more difficult. If you end up on ADT, it makes it much harder as well.

Sounds like you’re doing great.

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Completeness is a vague term depending on how you look at it. You can't help how u are so in a sense you are complete. You are too hard on yourself. Your partner as you put it by what you say understands I think about it 2 but if that's what a marriage is all about them I'd rather have remained single Love is patient and kind without any conditions.

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Profile picture for jeff Marchi @jeffmarc

@madisonman0326
It is strange that a radiologist would tell you that would happen right away. Most men who have radiation can get an erection after, A few years later, it frequently becomes more difficult. If you end up on ADT, it makes it much harder as well.

Sounds like you’re doing great.

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@jeffmarc
Thanks for the heads up.
She went through the impotency blues with husband number two and he just stopped trying. This ultimately was a factor in their divorce.
I will let her know what lay ahead so she can consider whether it’s worth continuing our relationship. She’s still an attractive woman so she may have a chance of finding a fully functional man.

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Profile picture for madisonman0326 @madisonman0326

@jeffmarc
Thanks for the heads up.
She went through the impotency blues with husband number two and he just stopped trying. This ultimately was a factor in their divorce.
I will let her know what lay ahead so she can consider whether it’s worth continuing our relationship. She’s still an attractive woman so she may have a chance of finding a fully functional man.

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@madisonman0326

When you’re in a spin class, you’re sitting on a bicycle seat. If those seats are narrow and press into your perineum, they cause erectile dysfunction in men. This is a common problem a lot of bike riders have. This could make your problem with ED worse. The thing is if you do something about it, it frequently increases the desire.

Usually radiation doesn’t prevent you getting an erection but being on ADT and Zytiga will reduce your testosterone so you will have little desire for sex And it can be hard to get an erection.

Some people get implants so they can still get erections, There is a very high satisfaction rate with people that have done this.

You can also use injections into the penis, which can give you a solid erection. They have Bimix and Trimix Injections that can be used and they work very well for most people.

It is also recommended that people take Cialis daily to keep the blood flow working properly.

You don’t have to give up. There are solutions.

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Profile picture for heavyphil @heavyphil

@madisonman0326 Hey buddy, While I am not qualified to diagnose your depression - or lack of it - I think what you are feeling is totally normal and relatable to many of us on the forum.
You were an athlete, went to seed, came roaring back like Rocky Balboa and then had the rug pulled out…how can you NOT feel less than elated??
Not being able to please your partner sexually is a BIG, BIG issue for all of us and there’s no easy answer; and no therapist (Although essential in true cases of depression) is gonna magically help you either. You can have an erection or you can’t; plenty of other ways to satisfy your partner while on ADT but your lower libido is not going to make you feel like going there most times.
The best thing IMO is to vocalize your emotions and fears directly to your partner - I did this with my wife and it really cleared the air about many things left unsaid.
As men, I think we are afraid to open up and ‘put things in her mind’ like having a boyfriend or leaving you for greener pastures…but it’s total nonsense - they are WAAAAAY ahead of us in the thought process and are far more perceptive than any ten of us combined!! Best,
Phil

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@heavyphil @mdisonman0326
I think we all suffer from some degree of depression, anxiety and stress with having PC and then the treatments that affect some more than others.

I am no where close to what I was prior to diagnosis and my treatments mentally. I am being treated for PTSD, anxiety/panic disorder but was prior to PC diagnosis.

So I relied on my psychiatric specialist to help me through my journey with PC. I think very importatn to consider doing mental health counseling. I also consider being truthful with your partner about your feelings. Most of the time you will hear "did not know you were feeling that way." Being honest really helps communications and feelings.

Now have posted that some spouses do not feel comfortable with advise. Some think don't want to say something wrong and make it worse and others are confronted of what should be said and withdraw which affects the spouse who sees and feels that.

There are great medications out there for depression and also lifestyle changes that can really help with mental outlook.

I hope all those reading these that are having problems and concerns will reallize not uncommon to feel that way and absolutely no negativity of reaching out for help from psychiatric department and open and honest discussions with partners.

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Profile picture for madisonman0326 @madisonman0326

@northoftheborder
Thank you. Actually, I was lost in the woods when my partner - let’s call her Ann - found me. My wife of 22 years had left me the previous year, I was obese and working an office job I detested. I met Ann in a singles group for middle aged people and I was smitten. She was an athlete, a cyclist, tall, blonde and fit. She wanted nothing to do with me because I had too many issues but she later found out through the rumor mill that I had once been an athlete so she pulled me off the rejection pile and decided she would make me her project. She had me join Weight Watchers and monitored my progress. I lost 63 pounds in two years. She then encouraged me to hire a coach - toward the end of my athletic career, I had been a short track speed skater - and I found one who was a retired marine DI. By age 58, I was back on the circuit and winning in the masters division and I owe all this to Ann, who believed in me when I didn’t.

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@madisonman0

What a wonderful uplifting story!

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Profile picture for jeff Marchi @jeffmarc

@madisonman0326
It is strange that a radiologist would tell you that would happen right away. Most men who have radiation can get an erection after, A few years later, it frequently becomes more difficult. If you end up on ADT, it makes it much harder as well.

Sounds like you’re doing great.

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@jeffmarc

At the risk of sounding pedantic, there is a large distinction between a radiation oncologist ( the specialist to whom you refer) and a radiologist. I practiced radiology (Interventional and Neuroradiology) for 40 years.

A radiologist interprets various imaging studies (PET, MRI, CT, US etc and reads plain films, with some specialty radiologists performing procedures-tumor ablation, angioplasty, biopsy, spine fracture stabilization, embolization, drainage of blocked kidney/ biliary systems etc).

A Radiation Oncologist uses radiation to treat cancer.

Again, apologize for minor detail correction but just a pet peeve of mine having practiced the specialty.

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Our stories are similar. Diagnosed at age 68, second marriage, G9( 4+5) prostate cancer with limited metastatic disease, had triple therapy with additional 6 weeks of pelvic radiation, When I was put on Lupron and my T fell to essentially zero I became depressed and anxious with the other side effects as well. My libido was compromised and my wife was less than supportive. I had ED and climaturia (urine leakage with orgasm). Our previously wonderful sex life disappeared.

My MO insisted I see a therapist and get on anti depressants which I did. I was eventually taken off Lupron and placed on TRT. I eventually divorced my wife. My libido returned. I met a wonderful woman who is understanding and has no issues with my history or climaturia. I currently use Trimix and my sex life is now wonderful again. I remain on the anti depressant and have no depression. My therapist plans to wean to me off the anti depressant in a few months.

So, in summary-sex can still be fulfilling even with ED. Depression can be treated. Life can be wonderful again!

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