I have asthma, emphysema, & bronchiectasis. Have been inhaling Budesonide for years with success and it doesn’t wear off becoming ineffective. I think doing biologic shots would do wonders for you though. My daughter and I both have had great success with them. Dupixent is our pulmonologist’s (Mayo Clinic) top choice but we also handled Xolair and Fasenra well. It’s a matter of trying them and finding what works for you without having a reaction.