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Support For Those Quitting Prolia

Osteoporosis & Bone Health | Last Active: Mar 2 8:42pm | Replies (266)

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Facing a choice. Please help. Just had new dexa results with gains in spine and femoral neck.
Ive taken Prolia twice as a means to retain great results of evenity. In the past I have taken alendronate for 3 years prior to forteo, forteo for 2, another 2 years is alendronate then 1 year of evenity. I am also in bhrt
My endocrinologist is suggesting one of two paths:

1/2 dose of zolendronic acid(I wanted 1/2 dose of reclast but a 1/2 dose is only available in infusion center and that would be the zolendronic acid), monitor for bone turnover with ctx and dexa and hope that the bhrt will help stave off osteoclast ramp up (Prolia rebound)

Second choice is remain on prolia. I do have some leg pain that has developed slowly after 2nd Prolia shot. Hard to tell if pain is due to my 77 year old body or Prolia.
Thoughts, ideas would be most welcome.

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Replies to "Facing a choice. Please help. Just had new dexa results with gains in spine and femoral..."

@gravity3
great news about increasing density gains.

It is fortunate you are being advised by an endo. My understanding is that there is usually only small rebound after Prolia is taken only once or twice. Is that your understanding.....sounds like you have been this route before?

Couple of questions:

1) I thought Reclast is the trade name for zolendronic acid so unsure what is meant here. Believe Reclast is also administered in infusion center? If the DEXA/CTX monitor shows Prolia rebound of concern, what is next step? Can you take another 1/2 dose of zolendronic acid? If no rebound, can you look forward to a drug holiday?

2) Are you in osteopenia territory? What is the area of most concern....spine or hips? Or equal concern?

I am not a fan of Prolia so my inclination would be to go the zolendronic acid route and then up my game on targeted nutrition and targeted targeted exercise while monitoring for rebound.

Has your endo given you any indication about what an CTX score might look like if rebound becomes a concern? Many of us are interested in that score.....