@nancy334

It is possible that the reduction of your Prednisone dose is causing havoc with your blood glucose levels. In the same way that high doses of Prednisone increases blood glucose levels --- tapering our prednisone dose lower can decrease blood glucose levels.

Are you taking any medications to control your blood glucose levels while on Prednisone? As the prednisone dose is reduced, its effect on blood glucose diminishes, but the body's natural production of cortisol takes time to recover. If you are using insulin or other diabetes medications, their doses may need adjustment.

The cortisol problem when we taper off Prednisone isn't fully appreciated. It is very difficult to taper off Prednisone. Hypoglycemia is a recognized symptom of low cortisol levels (adrenal insufficiency).

I'm not qualified to give you any medical advice. However, I wouldn't reduce your Prednisone dose any further until you get evaluated. When Actemra allowed me to taper off Prednisone, I was ordered to stay on 3 mg of Prednisone and wait for my cortisol level to improve. I was told not to taper any lower than 3 mg.

I didn't ever develop diabetes when I took Prednisone. However my pancreas was pumping out a lot of insulin. My insulin level was very high. Nothing was ever said about a high insulin level while I took prednisone. The endocrinologist said I had steroid-induced insulin resistance which precedes the development of diabetes. All I know is how complicated hormones are and how difficult it was for me to taper off Prednisone.
https://my.clevelandclinic.org/health/diseases/24178-hyperinsulinemia
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I think you might need a referral to an endocrinologist to assist you with your hypoglycemia.