PSA levels started to rise again but negative PSMA PET

Posted by thepilotusa @thepilotusa, Mar 21 5:59pm

After radical prostatectomy my PSA levels started to rise. At PSA 0.5 I had a PSMA PET CT which showed no radiotacer-avid disease. At PSA 1.12 I had another PSMA image and, again, showed no radiotacer-avid disease. Has anyone gone thru this experience? Why my PSA levels continue to rise but nothing shows on the images? Lab used F-18 agent.

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heavyphil | @heavyphil | Nov 12 8:19am

In reply to @sammiam "yes, but the liver damage if it happens is caused by drugs. I'm discussing this with..." + (show)

@sammiam I had liver enzymes rise quite a bit while on Orgovyx (6mos) and was very concerned.
However, my RO told me the numbers would have to be FIVE times higher before ‘liver damage’ was even a concern.
We’re all different so your liver may react to a greater or lesser extent…Best,
Phil

jeff Marchi | @jeffmarc | Nov 12 11:00am

In reply to @heavyphil "@sammiam I had liver enzymes rise quite a bit while on Orgovyx (6mos) and was very..." + (show)

@heavyphil
Just for the other point of view about liver issues. Eight years of ADT 2 1/2 years of Orgovyx My liver function, which is tested every month for the last eight years is just normal.

Everybody’s different.

SteveNovach | @debrazd | Nov 13 8:00am

In reply to @kujhawk1978 "Maybe switch agents?" + (show)

@kujhawk1978 Ga68 agent detected mine at 0.42
Was small activity in prostate bed.

SteveNovach | @debrazd | Nov 13 8:10am

In reply to @cwd21682nd "You should ask for an MRI it may show what the PT Scan cannot see.?" + (show)

@cwd21682nd Yes that's exactly what I'm waiting on .After the Pet/ct showing some minor activity in the prostate bed at 0.52 agent was Ga68 in EU don't know what's used in US. My Rad/Oncologist. wants me to repeat MRI to maybe pin point where iz this activity. Planing to zepp it with cyber.

kujhawk1978 | @kujhawk1978 | Nov 13 9:24am

In reply to @debrazd "@kujhawk1978 Ga68 agent detected mine at 0.42 Was small activity in prostate bed." + (show)

@debrazd

That's great and given the statistics, a possible outcome of the scan to inform a treatment decision.

For some, insurance issues may come into play, if a scan is done at levels such as yours and are negative, the insurance company may not approve the next one for a period of time.

Then there is the question of when to pull the trigger on treatment. For some, they and their medical team are comfortable with letting PSA rise to higher levels thus delaying treatment and its side effects.

There is no single right choice for imaging or treatment but there are a plethora of good choices.

SteveNovach | @debrazd | Nov 15 10:55am

In reply to @kujhawk1978 "@debrazd That's great and given the statistics, a possible outcome of the scan to inform a..." + (show)

@kujhawk1978 Yes that is a problem..souch problems shouldn't interfere with our decisions how or when to continue with procedures.
I'm in EU and coordinating with my Oncologist and Radiology with no issues with insurance, I can act on there's recommendation and yet my word is the last on accepting the procedures. Gov.helth insurance covers everything.