@starlight1 Yes, it's anxiety provoking being on a new medication. The list of possible "adverse events" [side effects] reads a little scary. Some will experience side effects right away, some months into treatment, and others not at all. Among the reasons I decided to start Brinsupri include: my doctor recommended it, so far it's the only FDA approved drug for bronchiectasis (the only kid on the block!), and I knew if I experienced untenable side effects I could stop and those side effects could be reversed.

Brinsupri is supposed to help with mucus plugging, a common finding on CT scans in bronchiectasis. Mucus plugging can lead to lung damage. So it becomes a trade-off. What did your doctor advise given the new rash on your hands? Did you see a dermatologist? I know it's early but have you seen any improvement in your bronchiectasis?

@starlight1 I started getting small callous like lesions on my legs after about two weeks. I had a couple of what looked like small open soars on my hands and arms. It wasn’t a rash though. There was one in my leg where the skin was peeling. I must say I am super sensitive to medications. My doctor at Mayo took me off brinsupri and I will see a dermatologist. We may try lowering the dose to 10 mg instead of 25mg after we see what the dermatologist says.