Start at the lowest dose and work your way up to the dosage your body can tolerate. Be ready to be extremely tired, have a headache that comes and goes, and be sure to receive medication for nausea. That being said, my primary symptom is skin sensitivity. At times, the bedsheet bothers me so much when touching my legs. It's a weird feeling. That being said, many days I have no desire for food whatsoever, and that has made my weight loss journey easier than ever. Eat lots of protein. And eat some more protein. Good luck!