I had a lumpectomy (stage 1 invasive ductal carcinoma) February of 2024. This was followed by 4 rounds of chemotherapy and 30 days of radiation. My tumor was estrogen positive and I have been on anastrozole (aromatase inhibitor) for 14 months. My recent bone scan showed that I had gone from osteopenia to osteoporosis, most likely due to the aromatase inhibitor which limits the estrogen my body produces. My oncologist strongly suggested Zometa by infusion once every 6 months for the next 3 years. I did not want to take it because of side effects I had read about. She pretty much insisted because they said the aromatase inhibitor is the "heavy hitter" in my cancer fight and if I don't want to do anything about the bone loss it causes, they may not want to treat me with the "heavy hitter" that is keeping my cancer at bay. I finally said I would go along with the treatment. I had my first infusion 5 days ago. 24 hours after the infusion I felt the flu-like symptoms everyone talks about. The aftereffects felt like when I went thru my rounds of chemotherapy but without the hair loss. The headaches and aches have now passed but yesterday a sadness and inability to concentrate has set in. I am 71 years old and have never been depressed in my life. I never saw psychological difficulties in the handouts given to me as one of side effects. I am seriously pushing myself to get out of bed and into the shower. Another serious push to get dressed. Feeling weepy and fighting tears for no good reason. I did a deep dive on the internet and saw that sadness and depression is a common side effect. Wish I had known beforehand. Can't wait for this feeling to pass. Has this happened to anyone else on this forum? If so, how long did it last?