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Keytruda side effects: How did you manage them?

Kidney Cancer | Last Active: Feb 5 4:01pm | Replies (32)

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I’m 78 year old male and had my left kidney removed with renal cell carcinoma on 9/24/2025. Today is 11/11/2025. I had my first Keytruda infusion on 11/7/2025, 400 mg.
Within 5 -7 hours I had severe muscle pan in both hands, arms and shoulders. I could not lift a water bottle with both hands for example.
I do have arthritis.
I took 40 mg prednisone that night and by morning I was so much better.
My oncologist doesn’t know what to do relative to Gavin the second infusion in 6 weeks. Trying to work with my rheumatologist to come up with a solution if I have a second infusion or whether the benefit of Keytruda is worth the pain.
What’s very frustrating to me is that there is no clear answer or direction. Don’t know what to do, if anything, at this point.

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Replies to "I’m 78 year old male and had my left kidney removed with renal cell carcinoma on..."

@mah7925
What degree of success did they have withe the nephrectomy? i.e., did they get all the cancer? Why are they having you take Keytruda?

@mah7925, how are you doing? Have you had any additional Keytruda infusions? How did it go?