@justwow The Mayo team believed the metastasis to my left lymph nodes were too extensive to risk surgery. Plus most surgeries end up needing radiation chemotherapy anyway. HPV+ SCC is very susceptible to radiation.

Ask the team if their institution is participating in the DART 2.0 trial, which tracks the DNA marker of the cancer cell death. Mine dropped to zero by week 4 and I was able to stop a week later (two weeks early - meaning fewer and less severe side effects).