I don't have anything to add to the other excellent responses to your question about the biopsy itself. I also had a transperineal biopsy and for me the procedure was very easy. They knocked me out and very minimal pain or discomfort when I woke up. The next day I started a 10 day road trip and I was fine. I don't remember their post-biopsy instructions, but whatever they were I'm sure I followed them strictly. The only thing I noticed worth mentioning is for about a week or so, when I had sex I'd have some dark fluid in my semen. I assume it was dried blood. That gradually went away over about 10 days or so. The annoying part was that after sex when small amounts of fluid would gradually release over a period of time it would discolor my underwear a bit. I think I started putting a thin pad in my underwear, knowing that'd happen. Like I said, I don't remember exactly how long it persisted but it went away pretty quickly (a week or two). I only mentioned it as it can make a bit of a mess if you aren't prepared for it. Best wishes.