Biopsy questions: Does it matter where it’s done?

Posted by stldadof4 @stldadof4, Nov 8, 2025

Hi. I’m new here and have really appreciated this group. I’m 57, PSA in the 5-7.5 range, but then had an Iso PSA result of 22.8.

Had an MRI last week which showed one suspicious 11 mm tumor (PIRADS 4 nodule at left mid gland peripheral zone. EPE grade 0, but T2WI score: 5 DWI score: 3 DCE: positive).

The urologist said I need a biopsy. He does the fusion kind, which sounds best from what I’ve read here. After that I’ll know what I’m dealing with, but all the indications seem like PC, but hopefully confined to the prostate. If so, I’m sure I’ll be back here looking for guidance from you all.

My question is about the biopsy itself. Does it matter where it’s done? The MRI was at Siteman Cancer Center in St. Louis, so a reputable place, and I know I can send it elsewhere to be reviewed if/when I’m evaluating treatment options.

Right now I’m planning to have the biopsy at the urologist’s surgery center. He apparently does these a lot. Curious to see if there are opinions about where to go for the biopsy. Does it matter where it’s done and who conducts it so long as it’s a reputable urologist and they are doing fusion?

If you have any other suggestions based on my results above, I’d appreciate those too. This is all new to me, and I don’t know anyone who’s been through this. Thanks in advance for your input.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

no its just a biopsy- he has exp.. get it done, then you know what you are dealing with ...if you do have PC, then you are catching it early and that is the best thing...early treatment saves you from more miserable treatments done the road

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It’s not so much a matter of where the biopsy is done as how it is done.

You want to get a Transperineal biopsy not a transrectal biopsy. The reason is the rectal biopsy has a much higher chance of infection. It also cannot reach all parts of the prostate.

Yes, you want to get the fusion biopsy because they use the MRI that shows the PIRADS 4 Tumor and allows him to directly get samples from it. It’s a much more accurate biopsy.

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Thank you for the helpful replies. I’ll make sure he is doing transperineal.

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@stidadof4
You would want a urologist who has experience in doing biopsies. Per you post he appear he is. You mentioned doing the Fusion and have had the MRI. That means he merges the MRI/Fusion to direct him where to do the biopsies. It is a more advanced accurate procedure (I had mine done this way). My urologist also did some outside the suspicious areas.

Have you asked how it will be done transrectal or transpernium? They are very different procedures. One is done through rectum and the other is through the transpernial. Transpernial usually involves a type of anesthesia and carries a less infection rate. Transrectal may have some type of sedation but carries a 1-2 % higher chance of infection which can be serious.

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I’m not a doctor. That being said I agree with others that suggest you go with the MRI guided biopsy. They are known for their accurate results.

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I don't have anything to add to the other excellent responses to your question about the biopsy itself. I also had a transperineal biopsy and for me the procedure was very easy. They knocked me out and very minimal pain or discomfort when I woke up. The next day I started a 10 day road trip and I was fine. I don't remember their post-biopsy instructions, but whatever they were I'm sure I followed them strictly. The only thing I noticed worth mentioning is for about a week or so, when I had sex I'd have some dark fluid in my semen. I assume it was dried blood. That gradually went away over about 10 days or so. The annoying part was that after sex when small amounts of fluid would gradually release over a period of time it would discolor my underwear a bit. I think I started putting a thin pad in my underwear, knowing that'd happen. Like I said, I don't remember exactly how long it persisted but it went away pretty quickly (a week or two). I only mentioned it as it can make a bit of a mess if you aren't prepared for it. Best wishes.

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Profile picture for retireditguy @retireditguy

I don't have anything to add to the other excellent responses to your question about the biopsy itself. I also had a transperineal biopsy and for me the procedure was very easy. They knocked me out and very minimal pain or discomfort when I woke up. The next day I started a 10 day road trip and I was fine. I don't remember their post-biopsy instructions, but whatever they were I'm sure I followed them strictly. The only thing I noticed worth mentioning is for about a week or so, when I had sex I'd have some dark fluid in my semen. I assume it was dried blood. That gradually went away over about 10 days or so. The annoying part was that after sex when small amounts of fluid would gradually release over a period of time it would discolor my underwear a bit. I think I started putting a thin pad in my underwear, knowing that'd happen. Like I said, I don't remember exactly how long it persisted but it went away pretty quickly (a week or two). I only mentioned it as it can make a bit of a mess if you aren't prepared for it. Best wishes.

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@retireditguy that is very helpful. Thanks for the heads up!

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Have the biopsy slides re-read at a center of excellence. One in five upgrades the aggressiveness. A PSMA PET CT Scan can see the 'avidness' of any target tumor, shop talk for aggressive appearance. It can also rule out most micro metastases.

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Profile picture for jeff Marchi @jeffmarc

It’s not so much a matter of where the biopsy is done as how it is done.

You want to get a Transperineal biopsy not a transrectal biopsy. The reason is the rectal biopsy has a much higher chance of infection. It also cannot reach all parts of the prostate.

Yes, you want to get the fusion biopsy because they use the MRI that shows the PIRADS 4 Tumor and allows him to directly get samples from it. It’s a much more accurate biopsy.

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@jeffmarc This!!! Exactly what my doctor did.

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Profile picture for thmssllvn @thmssllvn

Have the biopsy slides re-read at a center of excellence. One in five upgrades the aggressiveness. A PSMA PET CT Scan can see the 'avidness' of any target tumor, shop talk for aggressive appearance. It can also rule out most micro metastases.

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@thmssllvn I will do that. Thanks for the suggestion.

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