@loplady One year in, I just have some occasional hot flashes, if you can even call them that - I just seem to “run hotter” a bit these days. And some leg/foot cramping - but I probably don’t drink enough water! I had the coronary calcium test done for my own peace of mind before starting, at the suggestion of nurse friends. If the result had been anything other than zero (excellent), I may not have started the drug, due to some history on one side of the family.