@jeffmarc I am sincerely grateful that you've had a good experience with Orgovyx. When I told my urologist that it was a good thing he didn't tell me about all the side effects, he said, "People have different results." The problematic chemical in Trimix is alprostadil (Prostaglandin). The issue is that it is the primary chemical causing blood flow for erections. People have lower reviews of results with Bimix. It's not the most important issue, though: if I were able to have erections, there's probably one day a month that I'd even care. ADT has lowered my libido and energy enough that physical intimacy isn't a reasonable expectation...The last time I attempted just foreplay as an expression of closeness, I had to apologize to my wife about halfway through that I was falling asleep. And that's despite my exercising 90 minutes each weekday. I feel better for a short time but I'm crashed by bedtime. I'm hoping to get more insight from the second medical oncologist for solutions to make life on ADT more livable. I'm extraordinarily stubborn, so I have no plans to give up treatment entirely, but I keep my expectations low.