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← Return to Stable elevation of PSA
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I just reached him. He's never been told his prostate is particularly large. Also, no history of prostatitis. He no longer bikes. Just a couple of hours of pickle ball daily.
As to PSA density: 25 years ago, ultrasound had been developed to measure prostate size, and it was proposed to look at a ratio of PSA versus prostate size or volume to try to normalize out the effect of enlarged prostate on PSA. I recall some promising abstracts at the AUA, but I wasn't aware it made it to clinical practice.
Replies to "I just reached him. He's never been told his prostate is particularly large. Also, no history..."
@drj His MRI report will tell how large (volume) his prostate is. That’s what to look for, rather than “not particularly large.”
With his most recent PSA result and most recent prostate volume (from the MRI report) he’ll be able to calculate his PSA Density. The MRI report might even mention it.
That may (or may not) explain his elevated PSA, while finding nothing else.
(How old is he?)
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@drj
Technical correction for accuracy. An ultrasound probe was developed for the prostate to help guide needle biopsies and reduce false negatives. With the introduction of PSA, it was then suggested that it could also be used to measure prostate size and differentiate PSA elevations due to BPH from PSA elevations due to PCa.