Update Evenity followed by 2 years of alendronate
So DEXA just showed that my 22.9% spine gain is now only 11% meaning I lost that much in a year. And femoral neck about the same loss. So I went backwards considerably but haven’t fractured. Have not seen doc yet (Nov 6)
Frustrated and sad. I had great results from Evenity after a year that continued after 1 year of alendronate and expected continued improvement. Nothing else has changed. I exercise regularly, resistance work, swimming and walking 4-5 miles daily. (very active) Vitamin D is 51. All labs good. Waiting on CTX. Last from May 2025 was 361.
I was hoping for a drug holiday after 2 full years of alendronate. I surprised myself as I tolerated it very well, never missed a dose! I just turned 69 and so far no one will give me HRT. I had a coronary calcium score that was zero. I was worried as my cholesterol was creeping up to 259 with an LDL of 151 but an HDL 66 so I started rosuvastatin 20 mg daily but after the coronary calcium dropped it to three times a week . Now cholesterol is 152 and LDL down to 69 maintaining HDL at 70. This is essentially the only change I made.
No fractures and vertebral fracture assessment was negative.
What do I do next? I need a long term plan. Can I do a short course of Evenity or will the alendronate blunt it. Was the alendronate not strong enough. Should I have gone right to reclast? Is it too late since I’ve already lost so much? I’m scared of Prolia. T-scores spine is now 2.3 and femoral neck is 3.0. I essentially lost BMD everywhere taking alendronate this last year! I just don’t understand. Any input most welcome 🙏
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@hikernurse
I finish Evenity in 4 months and my endocrinologist is set on prolia too...I just hate doing it!!! I wish there was something else.
@grammy9
I wish there was also. I will be researching. The alendronate was good for me for the first year after evenity. I continued to gain both in hip and spine. My spine was -1.6 and I was counting on a continued gain after the next 12 months but unfortunately I lost and back to 2.6 spine and hip back to -3.0. My initial was -3.3. So I’m hopeful another round of Evenity and then not sure. My doc said prob not reclast since it is a bisphosponate and since it didn’t hold he didn’t think reclast was strong enough. I’m thinking maybe one dose of prolia followed by reclast. I do plan to talk it over with Dr McCormick.
Please let me know what you decide. Has there ever been anyone go on Forteo or Tymlos after Evenity?
I am scared of being on Prolia forever and I am 63. Also, the jaw issues really concern me. What don't you like about Prolia?