← Return to Bone turnover markers (CTX and P1NP): do you have a baseline?

Discussion
Comment receiving replies
Profile picture for gently @gently

hi, dale. Bone markers measure residue in your blood or urine that is left by cells called osteoblasts building bone and the residue left by cells called osteoclasts that disintegrate the bone.
The most common and (I think) most reliable are P1NP for the building cells and CTX for the disintegrating cells.
These tests can be used to determine whether a medication is effective for you, so that you don't have to wait for dexa results.
Oral bisphosphonates have been the mainstay against osteoporosis, and are commonly given to patients whose T scores are under -2,5. There are injectable bisphosphonates zoledronate in the form of Reclast and Zoloft. They can deliver a higher dose because much of the oral dose is lost in the stomach. Then there are the anabolic injectables Tymlos, Forteo, Evenity--thought to be half anabolic and half antiresorptive. And finally Prolia which is antiresorptive through a different mechanism than the bisphosphonates.

Jump to this post


Replies to "hi, dale. Bone markers measure residue in your blood or urine that is left by cells..."

@gently
Thank you for the explanation about bone markers; very appreciated.
My second question was about Risedronate. Do you or anyone you may know have had this bisphosphonate.? This will be my first medication for osteoporosis and honestly I am very concerned about all the bad things I read about the meds. One last question, are the bone markers tests usually given without having to ask the doctors about them?
Thank You!!