I have been taking anastrazole for over five years. I have had no negative side effects from this medication. It does make it harder to lose weight so there is that, but in the bigger picture, it provides me with some protection over a recurrence of my breast cancer. You read a lot of posts from people who have problems. That is legitimate. But you have to remember is that there are a lot even more people on medication‘s like anastrozole who do not have problems and they tend to not post as often in my opinion. I keep up on reading about medications. I am on. One thing I have learned about anastrozole over the past few years is that in addition to providing protection against a recurrence of breast cancer it also seems to be providing protection against development of dementia, which runs in my family. I trust my oncologist and when I met with him a couple of years back, he specifically asked if I was having problems with the anastrozole.I told him that I was not, the major challenge I was facing was an inability to lose weight. He told me that one of the side effects of Anastrazole is that losing weight is more difficult. I was working with my primary care doctor and taking medication which did allow me to lose some weight. My oncologist said to keep on doing that and asked if I was willing to continue to take the medication. I told him I would continue to take this medication for as long as he would continue to prescribe it because I firmly believed it was an active step in keeping me cancer, free and alive. He smiled and said he absolutely agreed with that. He was glad that I was not having some of the horrific side effects that some people do, so there is that. But you have to realize that there are probably more people out there taking AI meds and NOT having problems than those who are having legit problems. It is truly an individual, case by case decision.