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Pancreatic Cancer Recurrence after Whipple
Pancreatic Cancer | Last Active: Nov 27, 2025 | Replies (117)Comment receiving replies
@stageivsurvivor What are your thoughts on Nalirifox vs Folfirinox? Same thing or better? Nalirifox is a chemotherapy regimen that consists of 4 different medicines, 3 of which are chemotherapy agents and one is similar to folic acid (from Drugs.com):
Onivyde (irinotecan liposomal), a chemotherapy agent encapsulated in a liposomal base to allow for more sustained blood levels of irinotecan
Oxaliplatin, another chemotherapy medicine that is a platinum-based alkylating agent that forms cross-links in DNA
Fluorouracil, an antimetabolite chemotherapy treatment that disrupts the formation of DNA
Leucovorin is a medicine similar to folic acid that is used to protect healthy cells from the side effects of chemotherapy agents.
Thanks!
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@lvtexas There is no clinical trial data yet comparing (m)Folfirinox to Nalirifox. To get FDA approval, it had to be either less expensive treatment (which it is not) or be better than a regimen it is being compared to. Gemzar/Abraxane was selected as the comparator, the likelihood it would be proven better than if it went head-to-head against (m)Folfirinox which has been the “gold standard” since its FDA approval in 2018 and Folfirinox that was the gold standard from 2011-2018.