@inquirer, Thank you so much. You totally understand. I understand the dilemma that you faced, too. After my surgery, I was offered the chance to be in a clinical study and forego the radiation, with the “wait and see” approach. After discussion with my kids and husband, they asked that I do it. It was so tempting, though, to make the other decision. We never really know what is the right thing to do, do we? What made me decide to do it is that the study paperwork stated that the survival rate was very good for POLe mutations, but it was unknown whether it was good just because of the mutation, or because of the mutation/surgery/radiation combination. I didn’t want to risk it. The high grade and substantial lymphovascular space invasion scared me, and I didn’t want to take a chance. Just think - in a few years when the clinical trial study is done, somebody else may not need to make that decision!