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← Return to Been on TRT for over 10yrs: Upcoming biopsy & PSA levels
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Been on TRT for over 10yrs: Upcoming biopsy & PSA levels
Prostate Cancer | Last Active: Nov 26, 2025 | Replies (34)Comment receiving replies
Well after researching, i was thinking the same thing, and that a MRI should come first, so i asked the doctor. He stated the big jump, and wants to go and find out now, and not wait. I can say when my levels went down into the 2's, it was them having me totally off testosterone, so it goes down when im not on TRT, but I guess not low enough to warrant in the safe zone.
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@mpersonne The response by the doctor is illogical. The standard of care is for an MRI, ideally mpMRI, prior to a biopsy. MRI's can be performed quickly. There is a reason that the best prostate cancer doctors in the world developed the standard of care methodology.
Per the latest guidelines, only if a mpMRI or a biomarker test (e.g. PSE) shows "High suspicion for clinically significant cancer" is the next step to perform an image-guided biopsy. NCCN Guidelines Version 2.2025, Further Evaluations and Indications for Biopsy.
encourage all male health care providers to encourage annual PSA testing.
If a urologist chooses to perform a biopsy, it should be a MRI-fused biopsy in order to provide you, and him, with the best statistically relevant data.